Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
| ▸ | ME1 | P48163 | 1/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265038 | 0.89 | OPRM1 (0.54) | DRD4HTR7HTR1ADRD2SIGMAR1 | |
| SCHEMBL5265027 | 0.84 | DRD4 (0.47) | DRD4HTR7HTR1ADRD2SIGMAR1 | |
| SCHEMBL5264783 | 0.81 | DRD2 (0.51) | DRD4HTR7HTR1ADRD2 | |
| SCHEMBL5266680 | 0.81 | SLC6A2 (0.47) | DRD4HTR7HTR1ADRD2SIGMAR1 | |
| SCHEMBL5268003 | 0.80 | SIGMAR1 (0.53) | HTR7HTR1ASIGMAR1MEN1KMT2A | |
| SCHEMBL5263985 | 0.80 | SIGMAR1 (0.47) | HTR7HTR1ASIGMAR1MEN1KMT2A | |
| SCHEMBL5263941 | 0.79 | MEN1 (0.57) | HTR7HTR1ADRD2MAPTADRA1D | |
| SCHEMBL5265422 | 0.79 | ADRA1D (0.57) | HTR7HTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL5270524 | 0.79 | MEN1 (0.54) | DRD4HTR7HTR1ADRD2MAPT | |
| SCHEMBL4318159 | 0.78 | ALDH1A1 (0.48) | DRD4HTR7HTR1ADRD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |