Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | USP19 | O94966 | 1/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643335 | 0.68 | MAPT (0.37) | CFTRGOPCALDH1A1KMT2AMAPT | |
| SCHEMBL3662833 | 0.66 | NOTUM (0.39) | ALDH1A1KMT2ASMN1; SMN2GAANPC1 | |
| SCHEMBL21151453 | 0.64 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL9369948 | 0.64 | CFTR (0.34) | CFTRGOPCALDH1A1KMT2AMAPT | |
| SCHEMBL1199564 | 0.64 | — | — | |
| SCHEMBL2522098 | 0.63 | — | — | |
| SCHEMBL11316228 | 0.63 | NISCH (0.36) | ALDH1A1KMT2AGAANPC1RAB9A | |
| SCHEMBL4633787 | 0.61 | MAPT (0.44) | CFTRGOPCALDH1A1KMT2AMAPT | |
| SCHEMBL3056752 | 0.61 | MAPT (0.39) | CFTRGOPCALDH1A1KMT2AMAPT | |
| SCHEMBL8656886 | 0.61 | MAPT (0.40) | CFTRGOPCALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |