Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618924 | 0.78 | NOTUM (0.36) | MAPTLMNANOTUMALDH1A1KDM4E | |
| SCHEMBL10628279 | 0.78 | CYP3A4 (0.40) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8618979 | 0.78 | MAPK14 (0.39) | MAPTNOTUMALDH1A1NPC1RAB9A | |
| SCHEMBL10628315 | 0.77 | MAOA (0.44) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8117201 | 0.77 | BRD4 (0.42) | NOTUMALDH1A1KDM4EGAANPC1 | |
| SCHEMBL8618626 | 0.71 | NOTUM (0.39) | MAPTNOTUMALDH1A1KDM4EHPGD | |
| SCHEMBL21151453 | 0.68 | ALDH1A1 (0.53) | MAPTLMNAHTTNOTUMALDH1A1 | |
| SCHEMBL5265708 | 0.68 | CFTR (0.34) | MAPTLMNAHTTNOTUMALDH1A1 | |
| SCHEMBL3056752 | 0.65 | MAPT (0.39) | MAPTLMNAHTTNOTUMPSMB8 | |
| SCHEMBL8656886 | 0.65 | MAPT (0.40) | MAPTLMNAHTTNOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479499-B1 | INHIBITORS OF TUBULIN POLYMERIZATION | NATIONAL SCIENCE COUNCIL (TW) | 2002-11-12 | — | — | US | claimed |
| US-4662905-A | REACTION PRODUCT OF COPPER SALT AND AN IMIDAZOLE, PYRAZOLE, TRIAZOLE, OR TETRAZOLE | Itaru Todoriki, Director of Agency of Industrial Science and Technology (JP) | 1987-05-05 | — | — | US | claimed |
| US-9029394-B2 | 2-phenyl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-12 | — | — | US | disclosed |
| US-9023867-B2 | Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-9023866-B2 | 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-8916655-B2 | Phosphazene blocked imidazole as latent catalyst for epoxy resins | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-12-23 | — | — | US | disclosed |
| EP-2468747-B1 | 2-Selenophene-4-quinolones as anticancer agents | UNIV CHINA MEDICAL (TW) | 2014-09-03 | — | — | EP | disclosed |
| EP-2455369-B1 | Derivatives of 2-aryl-4-quinolones having an aminoalkyl group as anticancer agents | UNIV CHINA MEDICAL (TW) | 2014-09-03 | — | — | EP | disclosed |
| EP-2097483-B1 | CURABLE SILICONE COMPOSITION | DOW CORNING TORAY SILICONE (JP) | 2014-08-20 | — | — | EP | disclosed |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-20130253006-A1 | 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| EP-2096924-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | China Medical University (TW) | 2009-09-09 | — | — | EP | disclosed |
| EP-2097483-A1 | CURABLE SILICONE COMPOSITION | Dow Corning Toray Silicone Company, Ltd. (JP) | 2009-09-09 | — | — | EP | disclosed |
| EP-2094758-A1 | CURABLE EPOXY RESIN COMPOSITION, CURED BODY THEREOF, AND USE THEREOF | Dow Corning Toray Co., Ltd. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008078662-A1 | CURABLE SILICONE COMPOSITION | DOW CORNING TORAY CO., LTD. (JP) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008070176-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008069333-A1 | CURABLE EPOXY RESIN COMPOSITION, CURED BODY THEREOF, AND USE THEREOF | DOW CORNING TORAY CO., LTD. (JP) | 2008-06-12 | — | — | WO | disclosed |
| US-6897316-B2 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | CHINA MEDICAL UNIVERSITY (TW) | 2005-05-24 | — | — | US | disclosed |
| US-20050032832-A1 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | CHINA MEDICAL UNIVERSITY (TW) | 2005-02-10 | — | — | US | disclosed |
| US-4662905-A | REACTION PRODUCT OF COPPER SALT AND AN IMIDAZOLE, PYRAZOLE, TRIAZOLE, OR TETRAZOLE | Itaru Todoriki, Director of Agency of Industrial Science and Technology (JP) | 1987-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032832-A1 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CHUK | MAPT 4128/4885LMNA 3189/4885HTT 3738/4885 |
| US-20130253006-A1 | 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | DDX5, DHX30, PPIP5K2 | MAPT 3672/4885LMNA 4703/4885HTT 2089/4885 |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | PPIP5K2, DDX5, DHX30 | MAPT 3843/4885LMNA 4539/4885HTT 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.