Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210038 | 0.84 | NOTUM (0.58) | NOTUMKDM4ERXFP1PDK2TSHR | |
| SCHEMBL30413010 | 0.84 | NOTUM (0.58) | NOTUMKDM4ERXFP1PDK2TSHR | |
| SCHEMBL11666945 | 0.79 | NOTUM (0.51) | NOTUMKDM4ERXFP1PDK2TSHR | |
| SCHEMBL3970760 | 0.74 | NOTUM (0.78) | NOTUMKDM4ETSHRTLR8ALDH1A1 | |
| SCHEMBL4718626 | 0.73 | BRD4 (0.43) | KDM4ETSHRNPC1TP53RAB9A | |
| SCHEMBL2871930 | 0.73 | ALDH1A1 (0.50) | KDM4ETSHRTP53SMN1; SMN2KMT2A | |
| SCHEMBL29354014 | 0.73 | ALDH1A1 (0.50) | KDM4ETSHRTP53SMN1; SMN2KMT2A | |
| SCHEMBL5266259 | 0.72 | ALOX15 (0.35) | KDM4ETSHRNPC1TP53RAB9A | |
| SCHEMBL3624979 | 0.72 | NOTUM (0.59) | NOTUMPDK2TSHRNPC1TP53 | |
| SCHEMBL537002 | 0.71 | ALDH1A1 (0.52) | KDM4ETSHRTP53SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844052-A1 | THIENO[2,3-D]PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | Pharmacia & Upjohn Company LLC (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006079916-A1 | THIENO [2,3-D] PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-08-03 | — | — | WO | disclosed |