Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RPA1 | P27694 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5270243 | 0.88 | SMN1; SMN2 (0.40) | RPA1SMN1; SMN2PTGS2ALDH1A1FYN | |
| SCHEMBL5269545 | 0.85 | ALDH1A1 (0.37) | KDM4EL3MBTL1MAPK1RPA1SMN1; SMN2 | |
| SCHEMBL5268373 | 0.85 | RPA1 (0.45) | RPA1SMN1; SMN2MDM2MCL1BCL2 | |
| SCHEMBL5267029 | 0.81 | GSK3B (0.38) | SMN1; SMN2PTGS2BCL2FYNDYRK1A | |
| SCHEMBL2919367 | 0.79 | RPA1 (0.62) | L3MBTL1RPA1MDM2MCL1BCL2 | |
| SCHEMBL5267080 | 0.79 | BCL2 (0.40) | RPA1SMN1; SMN2MDM2MCL1BCL2 | |
| SCHEMBL5522493 | 0.78 | KDM4C (0.51) | KDM4EALDH1A1TSHRKDM5AKDM4C | |
| SCHEMBL5269886 | 0.78 | RPA1 (0.54) | L3MBTL1RPA1SMN1; SMN2MDM2MCL1 | |
| SCHEMBL5269263 | 0.78 | RPA1 (0.40) | KDM4EL3MBTL1RPA1SMN1; SMN2MDM2 | |
| SCHEMBL5526232 | 0.77 | MARS1 (0.46) | KDM4ERPA1SMN1; SMN2PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-11-01 | — | — | US | disclosed |
| EP-1785418-A1 | PYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | PTGER1, PTGS1, PTGER2 | KDM4E 3557/4885L3MBTL1 4767/4885MAPK1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.