Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | POLQ | O75417 | 2/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268373 | 0.90 | RPA1 (0.45) | SMN1; SMN2ALDH1A1TSHRKDM5AKDM4C | |
| SCHEMBL5266512 | 0.88 | KDM4E (0.42) | SMN1; SMN2PTGS2ALDH1A1TSHRFYN | |
| SCHEMBL5269292 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2PTGS2KDM5AKDM4CKDM5B | |
| SCHEMBL5267693 | 0.85 | ALDH1A1 (0.40) | SMN1; SMN2PTGS2ALDH1A1TSHRJAK1 | |
| SCHEMBL5526892 | 0.85 | ALDH1A1 (0.39) | ALDH1A1TSHRKDM5AKDM4CKDM5B | |
| SCHEMBL5267029 | 0.81 | GSK3B (0.38) | SMN1; SMN2PTGS2FYNJAK1ALOX5 | |
| SCHEMBL5269005 | 0.81 | GABRA1 (0.51) | PTGS2ALOX5GABRA1MALT1 | |
| SCHEMBL5522342 | 0.79 | JMJD6 (0.39) | SMN1; SMN2PTGS2ALDH1A1TSHRKDM5A | |
| SCHEMBL5526232 | 0.78 | MARS1 (0.46) | SMN1; SMN2PTGS2ALDH1A1TSHRFYN | |
| SCHEMBL5269545 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2PTGS2ALDH1A1TSHRALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-11-01 | — | — | US | disclosed |
| EP-1785418-A1 | PYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | PTGER1, PTGS1, PTGER2 | SMN1; SMN2 3490/4885PTGS2 4/4885ALDH1A1 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.