Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.54 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955495 | 0.86 | LMNA (0.66) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL5267338 | 0.84 | PPARG (0.48) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL5265736 | 0.83 | RAB9A (0.49) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL5266759 | 0.82 | ALDH1A1 (0.46) | SNCANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6544935 | 0.82 | GPR27 (0.72) | GPR27AVPR2SNCANPC1RAB9A | |
| SCHEMBL954639 | 0.81 | RAB9A (0.64) | NPC1RAB9ALMNATDP1ALDH1A1 | |
| SCHEMBL8220374 | 0.80 | KDM4E (0.62) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL16692879 | 0.79 | LMNA (0.46) | SNCANPC1RAB9AHTTLMNA | |
| SCHEMBL954020 | 0.79 | KMT2A (0.52) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL5265208 | 0.79 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |