Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30251078 | 0.81 | ALDH1A1 (0.53) | AKT1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL1983678 | 0.81 | ALDH1A1 (0.53) | AKT1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL13646651 | 0.79 | ALDH1A1 (0.58) | AKT1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL14283919 | 0.76 | AKT1 (0.46) | AKT1ALDH1A1KDM4EMAPTPDPK1 | |
| SCHEMBL9303654 | 0.75 | AKT1 (0.65) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL15441596 | 0.75 | AKT1 (1.00) | AKT1MAPTPDPK1PHLPP1ILK | |
| SCHEMBL10403858 | 0.75 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTGAAHPGD | |
| Cyclolanceaefolic Acid SCHEMBL27831084 | 0.74 | MAPT (0.49) | AKT1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL10402573 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL30836817 | 0.72 | ALDH1A1 (0.47) | AKT1ALDH1A1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856040-A2 | NOVEL LIPOXYGENASE INHIBITORS | Eli Lilly and Company (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006093547-A2 | NOVEL LIPOXYGENASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060193797-A1 | Chroman derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060193797-A1 | Chroman derivatives as lipoxygenase inhibitors | NR0B1, ALOX5, ALOX15B | AKT1 2143/4885ALDH1A1 757/4885KDM4E 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.