Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5270533 | 0.89 | MEN1 (0.47) | LMNAALDH1A1MEN1KMT2AROCK2 | |
| SCHEMBL5271648 | 0.86 | KMT2A (0.54) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5269714 | 0.86 | ROCK2 (0.54) | HDAC1ROCK2TRPV1EPHX2NR1H4 | |
| SCHEMBL5265952 | 0.84 | KMT2A (0.52) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5267185 | 0.82 | POLB (0.48) | LMNAALDH1A1MEN1KMT2AROCK2 | |
| SCHEMBL4279642 | 0.82 | HDAC1 (0.50) | LMNAKMT2AHDAC1ROCK2EPHX2 | |
| SCHEMBL5270571 | 0.81 | KMT2A (0.59) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5268095 | 0.81 | MAPT (0.53) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5268751 | 0.81 | LMNA (0.53) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5274230 | 0.81 | HPGD (0.49) | ALDH1A1KMT2AHDAC1ROCK2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |