Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467970 | 0.81 | AGER (0.47) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL3811903 | 0.78 | DCUN1D1 (0.58) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL21410210 | 0.76 | DCUN1D1 (0.57) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL5744569 | 0.76 | DCUN1D1 (0.52) | AGERMTNR1ADCUN1D1ALDH1A1SLC6A2 | |
| SCHEMBL17870701 | 0.74 | DCUN1D1 (0.51) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL619150 | 0.73 | SLC6A2 (0.71) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL6622412 | 0.73 | DCUN1D1 (0.54) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL15521608 | 0.72 | DCUN1D1 (0.60) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL528019 | 0.72 | MBTPS1 (0.45) | AGERMTNR1ADCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL2233154 | 0.72 | AGER (0.58) | AGERMTNR1ADCUN1D1ALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |