Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5273077 | 0.92 | ALDH1A1 (0.42) | ALDH1A1MAPK1TSPOKDM4ELMNA | |
| SCHEMBL5268584 | 0.87 | GABRA1 (0.41) | ALDH1A1MAPK1TSPOKDM4ELMNA | |
| SCHEMBL5268891 | 0.87 | KDM4E (0.41) | ALDH1A1TSPOKDM4ELMNAALB | |
| SCHEMBL5272481 | 0.86 | LMNA (0.37) | ALDH1A1MAPK1KDM4ELMNAALB | |
| SCHEMBL5275273 | 0.86 | GABRA1 (0.37) | ALDH1A1MAPK1KDM4ELMNAALB | |
| SCHEMBL5267778 | 0.85 | GABRA1 (0.36) | ALDH1A1MAPK1KDM4ELMNAALB | |
| SCHEMBL5272397 | 0.84 | SMN1; SMN2 (0.42) | SLC2A2 | |
| SCHEMBL5269079 | 0.84 | KDM4E (0.38) | ALDH1A1POLBMAPK1KDM4EHPGD | |
| SCHEMBL5270748 | 0.83 | NTRK1 (0.41) | ALDH1A1MAPK1TSPOKDM4ELMNA | |
| SCHEMBL5270250 | 0.83 | TSPO (0.42) | ALDH1A1TSPOKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | claimed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | claimed |
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | disclosed |