Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724635 | 0.85 | KDM4E (0.36) | CA12CA2CA9CA14CA1 | |
| SCHEMBL28864446 | 0.78 | AOC1 (0.37) | CA12CA2CA9CA14CA1 | |
| SCHEMBL20481226 | 0.77 | CA12 (0.37) | CA12CA2CA9CA14CA1 | |
| SCHEMBL24200150 | 0.76 | CA12 (0.36) | CA12CA2CA9CA14CA1 | |
| SCHEMBL15777428 | 0.74 | RORC (0.34) | CA12CA2CA9CA14CA1 | |
| SCHEMBL15776169 | 0.74 | CA12 (0.33) | CA12CA2CA9CA14CA1 | |
| SCHEMBL28026353 | 0.74 | RORC (0.34) | CA12CA2CA9CA14CA1 | |
| SCHEMBL1400223 | 0.72 | HTR1A (0.39) | — | |
| SCHEMBL20190681 | 0.71 | HTT (0.41) | CHUK | |
| SCHEMBL15475790 | 0.70 | CA12 (0.33) | CA12CA2CA9CA14CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |