Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006783 | 0.72 | TDP1 (0.49) | NR3C2 | |
| SCHEMBL21722444 | 0.72 | TDP1 (0.49) | NR3C2 | |
| SCHEMBL528021 | 0.70 | HTR1A (0.42) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL30671511 | 0.68 | HTR6 (0.36) | SLC6A2SLC6A4HTR1ASLC6A3HTR6 | |
| SCHEMBL28727044 | 0.68 | HTR2C (0.69) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL13726844 | 0.67 | TDP1 (0.46) | HTR6NR3C2 | |
| SCHEMBL330081 | 0.66 | HTR2C (1.00) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL29891667 | 0.66 | HTR2C (1.00) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL24716111 | 0.66 | HTR2C (0.56) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL30626631 | 0.66 | HTR2C (0.56) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |