Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340751 | 0.85 | ERCC1 (0.36) | KDM4EALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL5989722 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3909614 | 0.80 | KMT2A (0.47) | SMN1; SMN2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL5990124 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL1340890 | 0.78 | KMT2A (0.44) | SMN1; SMN2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL5278117 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2KDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL5285314 | 0.77 | AAK1 (0.49) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL7920995 | 0.77 | HDAC3 (0.48) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL5323199 | 0.77 | HDAC3 (0.48) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL5280460 | 0.77 | KDM2B (0.49) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |