Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2683892 | 1.00 | RORC (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2683813 | 0.96 | KMT2A (0.36) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2685056 | 0.95 | REN (0.38) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2685054 | 0.94 | REN (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL4539966 | 0.94 | REN (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2683870 | 0.94 | KMT2A (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL5279111 | 0.94 | REN (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2684035 | 0.94 | REN (0.35) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL3902743 | 0.94 | PKM (0.37) | RORCRENKMT2ACYP2C9POLB | |
| SCHEMBL2683799 | 0.94 | KMT2A (0.35) | RORCRENKMT2ACYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863763-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103275-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |