Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2683870 | 1.00 | KMT2A (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL2683813 | 0.95 | KMT2A (0.36) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL2683892 | 0.94 | RORC (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL2685056 | 0.94 | REN (0.38) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL5281822 | 0.94 | RORC (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL3902743 | 0.94 | PKM (0.37) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL2685054 | 0.94 | REN (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL4539966 | 0.94 | REN (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL2684035 | 0.94 | REN (0.35) | KMT2ACYP2C9RENPOLBRORC | |
| SCHEMBL5279111 | 0.94 | REN (0.35) | KMT2ACYP2C9RENPOLBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115859-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | HEROLD PETER (CH) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115859-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | REN, AGTR1, AGTR2 | KMT2A 3806/4885CYP2C9 976/4885REN 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.