Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285655 | 0.87 | MAPT (0.33) | KDM4EMAPTHPGDHSD17B10TDP1 | |
| SCHEMBL5279300 | 0.85 | KMT2A (0.40) | MAPTHSD17B10MEN1KMT2ATDP1 | |
| SCHEMBL5277972 | 0.85 | MAPT (0.38) | KDM4EMAPTHSD17B10MEN1KMT2A | |
| SCHEMBL5288509 | 0.85 | KMT2A (0.36) | KDM4EMAPTHPGDHSD17B10MEN1 | |
| SCHEMBL5280563 | 0.85 | KMT2A (0.38) | KDM4EMAPTHPGDMEN1KMT2A | |
| SCHEMBL5277022 | 0.81 | THRB (0.36) | KDM4EMAPTHPGDHSD17B10MEN1 | |
| SCHEMBL5281418 | 0.81 | KDM4E (0.35) | KDM4EMAPTHPGDHSD17B10NOTUM | |
| SCHEMBL5281217 | 0.81 | NCEH1 (0.34) | KDM4EMAPTHPGDHSD17B10MEN1 | |
| SCHEMBL6784280 | 0.80 | NOTUM (0.40) | KDM4EMAPTHPGDHSD17B10NOTUM | |
| SCHEMBL14341822 | 0.71 | NOTUM (0.34) | KDM4EMAPTHPGDNOTUMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474414-B1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1474414-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | Aventis Pharma Deutschland GmbH (DE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066620-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-08-14 | — | — | WO | disclosed |