Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778221 | 0.83 | MAPT (0.44) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL5285655 | 0.78 | MAPT (0.33) | MAPTKDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14342068 | 0.76 | ALDH1A1 (0.32) | KDM4EHPGDALDH1A1 | |
| Formic Acid SCHEMBL6779721 | 0.73 | KLK1 (0.33) | HPGDALDH1A1 | |
| Formic Acid SCHEMBL6779717 | 0.73 | KLK1 (0.33) | HPGDALDH1A1 | |
| SCHEMBL5277022 | 0.71 | THRB (0.36) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL5281418 | 0.71 | KDM4E (0.35) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL6778213 | 0.65 | ALDH1A1 (0.37) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28684572 | 0.65 | HSD17B10 (0.55) | NCEH1KDM4EMTNR1AMTNR1BLMNA | |
| SCHEMBL29525161 | 0.64 | HSD17B10 (0.67) | KDM4EMEN1KMT2AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474414-B1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1474414-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | Aventis Pharma Deutschland GmbH (DE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066620-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-08-14 | — | — | WO | disclosed |