Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038360 | 0.88 | IDO1 (0.36) | IDO1MMP9MMP8KMT2AMEN1 | |
| SCHEMBL5282628 | 0.84 | MMP9 (0.43) | IDO1MMP9MMP8KMT2AMEN1 | |
| SCHEMBL8258456 | 0.74 | IDO1 (0.42) | IDO1MMP9MMP8NPBWR1KDM4E | |
| SCHEMBL6038167 | 0.71 | MMP9 (0.40) | IDO1MMP9MMP8KMT2AMEN1 | |
| SCHEMBL6037917 | 0.69 | IDO1 (0.50) | IDO1MMP9MMP8CCKBROPRD1 | |
| SCHEMBL5283091 | 0.69 | IDO1 (0.59) | IDO1MMP9MMP8KDM4E | |
| SCHEMBL5283086 | 0.69 | IDO1 (0.59) | IDO1MMP9MMP8KDM4E | |
| SCHEMBL6037979 | 0.68 | ALDH1A1 (0.46) | MMP9MMP8KMT2AMEN1LMNA | |
| SCHEMBL5283128 | 0.68 | ALDH1A1 (0.46) | MMP9MMP8KMT2AMEN1LMNA | |
| SCHEMBL31275589 | 0.68 | MMP9 (0.44) | IDO1MMP9MMP8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | claimed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | claimed |
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |