Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27473723 | 1.00 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL5875372 | 1.00 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL5283313 | 0.93 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL372690 | 0.93 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL5874493 | 0.93 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL5272119 | 0.91 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL28197315 | 0.91 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL2201840 | 0.91 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL7208557 | 0.91 | ALDH1A1 (0.90) | ALDH1A1PABPC1MEN1KMT2ANPC1 | |
| Quinoline SCHEMBL1783847 | 0.89 | ALDH1A1 (0.71) | ALDH1A1PABPC1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102458130-A | Method for increasing the vigor and/or crop yield of agricultural plants under substantially absent pathogen pressure | BASF SE | 2012-05-16 | — | — | CN | claimed |
| CN-113527305-A | Pharmaceutically acceptable salts of quinoline TGF-beta 1 inhibitor and preparation method thereof | 南京圣和药物研发有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2019186520-A1 | A PROCESS FOR THE PREPARATION OF LIFITEGRAST | AUROBINDO PHARMA LIMITED (IN) | 2019-10-03 | — | — | WO | disclosed |
| CN-106924264-A | Sigma ligands for preventing and/or treating postoperative pain | 埃斯特韦实验室有限公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-101785470-B | Combinations of phenylsulphonyl urea herbicides and safeners | HOECHST SCHERING AGREVO GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-102802410-A | Composition comprising a pesticide and an alkoxylate of a branched nonamine | BASF SE | 2012-11-28 | — | — | CN | disclosed |
| CN-102792969-A | Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations | MONSANTO TECHNOLOGY LLC | 2012-11-28 | — | — | CN | disclosed |
| CN-102791128-A | Noxious organism control agent composition for agricultural and horticultural applications, and use thereof | NIHON NOHYAKU CO LTD | 2012-11-21 | — | — | CN | disclosed |
| CN-102724868-A | Production of pesticide granulates in a spouted bed apparatus | BASF SE | 2012-10-10 | — | — | CN | disclosed |
| CN-102711456-A | Composition comprising a pesticide and an alkoxylate of 2-propylheptylamine | BASF SE | 2012-10-03 | — | — | CN | disclosed |
| CN-1553769-A | Herbicide and safening combinations | �Ϻ���ͨ��ѧ | 2004-12-08 | — | — | CN | disclosed |
| CN-1178938-C | 1,2-annelated quinoline derivatives | ղɭҩҵ����˾ | 2004-12-08 | — | — | CN | disclosed |
| CN-1520407-A | Herbicidally substituted pyridines, their preparation and their use as herbicides and plant growth regulators | �Ϻ���ͨ��ѧ | 2004-08-11 | — | — | CN | disclosed |
| CN-1503626-A | Herbicidal composition containing benzoylcyclohexanediones and safeners | �Ϻ���ͨ��ѧ | 2004-06-09 | — | — | CN | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| CN-1090631-C | Heterocyclic compound, preparation process thereof and medicinal composition containing same | SEUER LAB (FR) | 2002-09-11 | — | — | CN | disclosed |
| CN-1331693-A | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-16 | — | — | CN | disclosed |
| CN-1206712-A | Heterocyclic compound, preparation process thereof and medicinal composition containing same | ADIR (FR) | 1999-02-03 | — | — | CN | disclosed |
| EP-0302792-B1 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI SA (FR) | 1994-10-26 | — | — | EP | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |