Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8763598 | 0.87 | PTPN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7298611 | 0.87 | PTPN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16355748 | 0.78 | PTPN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6698814 | 0.77 | PTPN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL346410 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2ARAB9ALTA4HGAA | |
| SCHEMBL8239448 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2ARAB9ALTA4HGAA | |
| SCHEMBL21837715 | 0.77 | CYP1A2 (0.55) | MEN1KMT2ARAB9ALTA4HL3MBTL1 | |
| SCHEMBL21837716 | 0.77 | CYP1A2 (0.55) | MEN1KMT2ARAB9ALTA4HL3MBTL1 | |
| SCHEMBL5024744 | 0.76 | PTPN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5024741 | 0.76 | PTPN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856046-A1 | CONJUGATES OF METAL COMPLEX HYDROXYPYRIDIN DERIVATIVES AND BIOMOLECULES AND THE USE THEREOF FOR PRODUCING AGENTS USED IN NMR DIAGNOSIS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-11-21 | — | — | EP | disclosed |
| EP-1828129-A1 | HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-09-05 | — | — | EP | disclosed |
| US-20070003484-A1 | Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules | SCHERING AG (DE) | 2007-01-04 | — | — | US | disclosed |
| US-20060292079-A1 | Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis | EPIX PHARMACEUTICALS, INC. | 2006-12-28 | — | — | US | disclosed |
| WO-2006069678-A1 | CONJUGATES OF METAL COMPLEX HYDROXYPYRIDIN DERIVATIVES AND BIOMOLECULES AND THE USE THEREOF FOR PRODUCING AGENTS USED IN NMR DIAGNOSIS | SCHERING AG (DE) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006069676-A1 | HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES | SCHERING AG (DE) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060292079-A1 | Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis | KLK3, HPGD, HAMP | PSEN1 3211/4885PSEN2 3200/4885APH1B 4785/4885 |
| US-20070003484-A1 | Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules | HPD, HAMP, KLK3 | PSEN1 2585/4885PSEN2 2870/4885APH1B 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.