Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5295212 | 0.93 | POLB (0.43) | POLBCDK9EGFRPARP1MEN1 | |
| SCHEMBL5306255 | 0.86 | ALDH1A1 (0.37) | POLBSMN1; SMN2ITGB3ITGAVITGA2B | |
| SCHEMBL5280577 | 0.83 | MAPT (0.38) | SMN1; SMN2ITGB3ITGAVITGA2B | |
| SCHEMBL5280316 | 0.81 | GHSR (0.47) | PARP1SMN1; SMN2KDM4E | |
| SCHEMBL5285256 | 0.80 | TP53 (0.48) | POLBMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2292264 | 0.79 | NPC1 (0.44) | POLBEGFRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2292578 | 0.78 | KDM4E (0.44) | POLBMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2294478 | 0.78 | NPC1 (0.48) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2299775 | 0.78 | HTR1E (0.53) | MEN1KMT2ATDP1 | |
| SCHEMBL2294510 | 0.78 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |