Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.32 |
| ▸ | ITGAV | P06756 | 2/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284712 | 0.86 | POLB (0.43) | POLBITGB3ITGAVITGA2BSMN1; SMN2 | |
| SCHEMBL5280577 | 0.85 | MAPT (0.38) | ALDH1A1RAB9AMAPTLMNAHTT | |
| SCHEMBL5295212 | 0.79 | POLB (0.43) | RAB9ALMNAPOLBNPC1SMN1; SMN2 | |
| SCHEMBL5301973 | 0.79 | RAB9A (0.40) | ALDH1A1RAB9AMAPTLMNAGAA | |
| SCHEMBL2292264 | 0.78 | NPC1 (0.44) | ALDH1A1RAB9AMAPTLMNAHTT | |
| SCHEMBL5280316 | 0.78 | GHSR (0.47) | ALDH1A1RAB9ALMNANPC1SMN1; SMN2 | |
| SCHEMBL2292578 | 0.77 | KDM4E (0.44) | ALDH1A1RAB9AMAPTLMNAHTT | |
| SCHEMBL2294478 | 0.77 | NPC1 (0.48) | RAB9AMAPTLMNAHTTNPC1 | |
| SCHEMBL5285256 | 0.77 | TP53 (0.48) | ALDH1A1RAB9AMAPTLMNAHTT | |
| SCHEMBL2294510 | 0.76 | SMN1; SMN2 (0.42) | ALDH1A1RAB9AMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |