Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529561 | 0.91 | SMN1; SMN2 (0.48) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528374 | 0.89 | SMN1; SMN2 (0.45) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528757 | 0.89 | MAPT (0.54) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL529360 | 0.88 | LMNA (0.67) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528969 | 0.88 | MAPT (0.60) | MAPTHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL528714 | 0.87 | SMN1; SMN2 (0.57) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528307 | 0.87 | KMT2A (0.63) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528077 | 0.87 | SMN1; SMN2 (0.57) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528646 | 0.87 | ALDH1A1 (0.59) | MAPTHTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL528058 | 0.86 | MEN1 (0.67) | MAPTHTTSMN1; SMN2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |