Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRK3 | P35626 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287709 | 0.90 | ALDH1A1 (0.59) | GRK2ALDH1A1HPGDRAB9AGRK3 | |
| SCHEMBL5285556 | 0.90 | MTNR1A (0.61) | GRK2MTNR1BMTNR1ATP53TSHR | |
| SCHEMBL8020284 | 0.89 | GRK2 (0.57) | GRK2MTNR1BMTNR1ATP53TSHR | |
| SCHEMBL5301594 | 0.89 | GRK2 (0.57) | GRK2TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL9795603 | 0.84 | PPARA (0.62) | TP53NPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL8021547 | 0.82 | ALDH1A1 (0.55) | GRK2PGRALDH1A1HPGDNPC1 | |
| SCHEMBL21194007 | 0.82 | MTNR1A (0.53) | GRK2MTNR1BMTNR1AALDH1A1HPGD | |
| SCHEMBL5282610 | 0.82 | GRK2 (0.58) | GRK2ALDH1A1GRK3FFAR1MITF | |
| SCHEMBL1797197 | 0.80 | MAPT (0.59) | TP53ALDH1A1NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL3655605 | 0.80 | MAPT (0.59) | TP53ALDH1A1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |