SCHEMBL5285045

SCHEMBL5285045

CCOC(=O)C(C#N)c1ccc2c(c1)OOC2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
GAA P10253 2/20 0.41
ALDH1A1 P00352 2/20 0.32
HSD17B10 Q99714 2/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
CYP2C19 P33261 1/20 0.32
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HTT P42858 1/20 0.32
KDM4E B2RXH2 2/20 0.32
MAPT P10636 2/20 0.32
TSHR P16473 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
CASP1 P29466 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5285048 0.79 CRHBP (0.52) MEN1KMT2ASMN1; SMN2GAACYP1A2
SCHEMBL10334595 0.77 SMN1; SMN2 (0.36) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL17466005 0.77 MEN1 (0.58) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL10034148 0.74 MEN1 (0.42) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL11017997 0.72 ALDH1A1 (0.44) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL6289274 0.72 SMN1; SMN2 (0.54) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL19492500 0.72 GAA (0.48) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL30021866 0.72 SLC6A3 (0.50) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL4683235 0.72 SLC6A3 (0.50) MEN1KMT2ASMN1; SMN2GAAALDH1A1
SCHEMBL5281573 0.71 GAA (0.53) MEN1KMT2ASMN1; SMN2GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313560-B1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2007-12-19 EP disclosed
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
US-6562989-B2 Bicyclopentyl iron ligand and transition metal catalyst YALE UNIVERSITY 2003-05-13 US disclosed
US-20030008768-A1 Catalyst for aromatic C-O, C-N, and C-C bond formation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed