Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284219 | 0.84 | HSD11B1 (0.53) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3163460 | 0.84 | HSD11B1 (0.47) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL1146161 | 0.81 | HSD11B1 (0.59) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL28539914 | 0.79 | HSD11B1 (0.61) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4159366 | 0.79 | HSD11B1 (0.57) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3157029 | 0.79 | HSD11B1 (0.57) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL28541788 | 0.79 | HSD11B1 (0.61) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3263174 | 0.78 | POLB (0.52) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8514629 | 0.77 | ALDH1A1 (0.62) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL30468568 | 0.77 | ALDH1A1 (0.62) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861079-A1 | ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097766-A1 | ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |