SCHEMBL5286009

SCHEMBL5286009

O=C(COc1ccccc1-c1ccccc1)Oc1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.56
TDP1 Q9NUW8 3/20 0.56
LMNA P02545 6/20 0.53
MAPK1 P28482 3/20 0.53
ALDH1A1 P00352 6/20 0.53
MAPT P10636 3/20 0.53
HTT P42858 4/20 0.51
USP2 O75604 1/20 0.50
KDM4E B2RXH2 6/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.46
PLA2G1B P04054 1/20 0.45
ATG4B Q9Y4P1 1/20 0.45
RAB9A P51151 2/20 0.44
POLB P06746 1/20 0.44
GLA P06280 1/20 0.44
PAX8 Q06710 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14327977 0.80 L3MBTL1 (0.64) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL5280082 0.79 MAPT (0.60) L3MBTL1LMNAALDH1A1MAPTKDM4E
SCHEMBL17720811 0.79 FABP3 (0.46) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL7873889 0.78 PTPN1 (0.61) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL13444685 0.77 L3MBTL1 (0.64) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL1947848 0.76 L3MBTL1 (0.72) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL5283928 0.76 MEN1 (0.51) L3MBTL1ALDH1A1MAPTRXRARXRB
SCHEMBL4906513 0.75 L3MBTL1 (0.70) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL13444680 0.75 L3MBTL1 (0.60) L3MBTL1TDP1LMNAMAPK1ALDH1A1
SCHEMBL30537993 0.74 L3MBTL1 (0.59) L3MBTL1TDP1LMNAMAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007001335-A2 RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY VICURON PHARMACEUTICALS INC. (US) 2007-01-04 WO disclosed
US-20060211603-A1 Ramoplanin derivatives possessing antibacterial activity VICURON PHARMACEUTICALS INC. (US) 2006-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211603-A1 Ramoplanin derivatives possessing antibacterial activity CLSPN, LMAN2, RPN2 L3MBTL1 2280/4885TDP1 2633/4885LMNA 3704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.