SCHEMBL5287521

SCHEMBL5287521

[CH2]n1c(=O)oc2ccc(C)cc21

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MIF P14174 3/20 0.53
▸ CD74 P04233 2/20 0.53
▸ KMT2A Q03164 3/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ POLB P06746 1/20 0.51
▸ RAB9A P51151 3/20 0.49
▸ TSHR P16473 2/20 0.49
▸ NPC1 O15118 1/20 0.49
▸ ALDH1A1 P00352 2/20 0.49
▸ MAPT P10636 3/20 0.48
▸ SMN1; SMN2 Q16637 3/20 0.48
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ TP53 P04637 1/20 0.48
▸ LMNA P02545 2/20 0.47
▸ THRB P10828 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5286912 0.85 MIF (0.53) MIFCD74KMT2AMEN1POLB
SCHEMBL434086 0.79 MIF (0.54) MIFCD74KMT2AMEN1POLB
SCHEMBL5544720 0.78 IDO1 (0.57) KMT2AALDH1A1TP53
SCHEMBL5546317 0.78 SIGMAR1 (0.44) KMT2AMEN1NPC1ALDH1A1TP53
SCHEMBL5546434 0.78 CD74 (0.53) MIFCD74KMT2APOLB
SCHEMBL24973060 0.78 MIF (0.53) MIFCD74KMT2AMEN1POLB
SCHEMBL16141180 0.75 MIF (0.50) MIFCD74KMT2AMEN1POLB
SCHEMBL13367744 0.75 MIF (0.66) MIFCD74KMT2AMEN1POLB
SCHEMBL14559257 0.73 RAB9A (0.64) MIFCD74KMT2AMEN1POLB
SCHEMBL2148987 0.73 THRB (0.69) MIFCD74KMT2AMEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007001335-A2 RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY VICURON PHARMACEUTICALS INC. (US) 2007-01-04 — — WO claimed
US-20060211603-A1 Ramoplanin derivatives possessing antibacterial activity VICURON PHARMACEUTICALS INC. (US) 2006-09-21 — — US claimed
WO-2007001335-A2 RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY VICURON PHARMACEUTICALS INC. (US) 2007-01-04 — — WO disclosed
US-20060211603-A1 Ramoplanin derivatives possessing antibacterial activity VICURON PHARMACEUTICALS INC. (US) 2006-09-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211603-A1 Ramoplanin derivatives possessing antibacterial activity CLSPN, LMAN2, RPN2 MIF 636/4885CD74 475/4885KMT2A 4422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback