SCHEMBL5288545

SCHEMBL5288545

CC(=O)CCOC(=O)N(CCNc1ccc(Cl)c(Cl)c1C(N)=O)C(=O)OC(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.32
CSF1R P07333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4043422 0.84 CA14 (0.32) AAK1CSF1R
SCHEMBL4043430 0.71
SCHEMBL5288536 0.70 DRD2 (0.32)
SCHEMBL8735080 0.64 CDC7 (0.37)
SCHEMBL8730869 0.64 CDC7 (0.37)
SCHEMBL4049896 0.64 CXCR2 (0.39)
SCHEMBL8735208 0.60 CDC7 (0.38)
SCHEMBL29410400 0.58 HDAC6 (0.39)
SCHEMBL2543733 0.58 CA14 (0.41)
SCHEMBL6678436 0.57 ALDH1A1 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846410-A2 DIHYDROQUINAZOLINONES AS 5HT MODULATORS Bristol-Myers Squibb Company (US) 2007-10-24 EP disclosed
WO-2006086464-A2 DIHYDROQUINAZOLINONES AS 5HT MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-08-17 WO disclosed