Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.61 |
| ▸ | HRH2 | P25021 | 3/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491545 | 0.89 | SIGMAR1 (0.67) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8909936 | 0.88 | ALDH1A1 (0.66) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8909943 | 0.88 | ALDH1A1 (0.66) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5281462 | 0.87 | SIGMAR1 (0.63) | HRH3SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8910535 | 0.82 | ALDH1A1 (0.69) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8693251 | 0.82 | ALDH1A1 (0.69) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7141641 | 0.82 | LTA4H (0.70) | HRH3SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| Oxalic Acid SCHEMBL8694605 | 0.80 | ALDH1A1 (0.66) | SIGMAR1KDM4EALDH1A1L3MBTL1 | |
| Oxalic Acid SCHEMBL5856199 | 0.80 | HRH3 (0.86) | HRH3MAOBHRH1HRH2KDM4E | |
| SCHEMBL492129 | 0.80 | HRH3 (1.00) | HRH3MAOBHRH1HRH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |