Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5293248 | 0.91 | USP2 (0.49) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5294746 | 0.79 | KDM4E (0.51) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25539639 | 0.76 | MEN1 (0.41) | ALOX5APMEN1KMT2A | |
| SCHEMBL30149908 | 0.73 | IL1B (0.39) | SMN1; SMN2ALOX5AP | |
| SCHEMBL20521428 | 0.73 | USP30 (0.40) | NPC1SMN1; SMN2ALOX5APALDH1A1MEN1 | |
| SCHEMBL1475583 | 0.71 | KDM4E (0.57) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5288124 | 0.71 | KDM4E (0.57) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5287827 | 0.71 | KDM4E (0.57) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1473531 | 0.70 | KDM4E (0.47) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8251140 | 0.70 | KDM4E (0.47) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007006714-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007006715-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2007-01-18 | — | — | WO | disclosed |