Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.72 |
| ▸ | HTR1B | P28222 | 9/20 | 0.72 |
| ▸ | HTR1A | P08908 | 7/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR2C | P28335 | 2/20 | 0.68 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.68 |
| ▸ | HTR3B | O95264 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | HTR1E | P28566 | 1/20 | 0.68 |
| ▸ | HTR1F | P30939 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | HTR3A | P46098 | 1/20 | 0.68 |
| ▸ | HTR5A | P47898 | 1/20 | 0.68 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.68 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.68 |
| ▸ | HTR6 | P50406 | 1/20 | 0.68 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27084735 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL30630304 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL132733 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL27221706 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL29351950 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL31098269 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL25330504 | 0.80 | HTR1D (0.97) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL26111484 | 0.80 | HTR1D (0.97) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL30630492 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL23069154 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | UNIV DUKE (US) | 2015-01-22 | — | — | US | disclosed |
| US-8877802-B2 | Antiparkinsonian action of phenylisopropylamines | Duke Univerity (US) | 2014-11-04 | — | — | US | disclosed |
| WO-2007016190-A2 | ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES | DUKE UNIVERSITY (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | HTR1D 129/4885HTR1B 41/4885HTR1A 29/4885 |
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | HTR1D 129/4885HTR1B 41/4885HTR1A 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.