Mebufotenin

Mebufotenin

SCHEMBL29351950

COc1ccc2[nH]cc(CCN(C)C)c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 8/20 1.00
HTR1A P08908 6/20 1.00
HTR1B P28222 6/20 1.00
HTR6 P50406 5/20 1.00
HTR2A P28223 4/20 1.00
HTR2C P28335 3/20 1.00
HTR7 P34969 3/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
HTR4 Q13639 2/20 1.00
HTR1E P28566 2/20 1.00
HTR2B P41595 2/20 1.00
HTR5A P47898 2/20 1.00
HTR3E A5X5Y0 1/20 1.00
HTR3B O95264 1/20 1.00
CYP2C9 P11712 1/20 1.00
HTR1F P30939 1/20 1.00
HTR3A P46098 1/20 1.00
MTNR1A P48039 1/20 1.00
MTNR1B P49286 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mebufotenin SCHEMBL27221706 1.00 HTR1D (1.00) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL31098269 1.00 HTR1D (1.00) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL132733 1.00 HTR1D (1.00) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL26111484 0.99 HTR1D (0.97) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL25330504 0.99 HTR1D (0.97) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL7205139 0.92 KMT2A (1.00) HTR1DHTR1AHTR1BHTR6HTR2A
SCHEMBL8868914 0.92 HTR1D (0.85) HTR1DHTR1AHTR1BHTR6HTR2A
SCHEMBL24497000 0.92 SLC6A4 (1.00) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL29992823 0.90 HTR1D (0.82) HTR1DHTR1AHTR1BHTR6HTR2A
Mebufotenin SCHEMBL26120710 0.90 HTR1D (0.82) HTR1DHTR1AHTR1BHTR6HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4577245-A1 DENDRIMER COMPOSITIONS FOR TARGETED DELIVERY OF PSYCHEDELIC THERAPEUTICS The Johns Hopkins University (US) 2025-07-02 EP claimed
CN-119923278-A Dendrimer compositions for targeted delivery of fantasy therapeutic agents 约翰霍普金斯大学 2025-05-02 CN claimed
WO-2024044756-A1 DENDRIMER COMPOSITIONS FOR TARGETED DELIVERY OF PSYCHEDELIC THERAPEUTICS THE JOHNS HOPKINS UNIVERSITY (US) 2024-02-29 WO claimed
WO-2023114529-A2 PHARMACOACTIVE FORMULATIONS FOR DELIVERY OF PSYCHEDELIC COMPOUNDS BENNES, INC. (US) 2023-06-22 WO claimed
WO-2022235587-A1 LIPID PRODRUGS OF TRYPTAMINE AND PHENETHYLAMINE PSYCHEDELICS AND USES THEREOF TERRAN BIOSCIENCES INC. (US) 2022-11-10 WO claimed
US-20220259147-A1 COMPOSITION COMPRISING A BENZOATE SALT OF 5-METHOXY-N,N-DIMETHYLTRYPTAMINE Beckley Psytech Limited (GB) 2022-08-18 US claimed
CN-113956188-A Synthesis method of N, N-dimethyl-5-methoxytryptamine 河北维达康生物科技有限公司 2022-01-21 CN claimed
CN-122005549-A Application of indole alkali compound in preparation of medicine or skin care product for treating or preventing skin diseases 南京效真生物科技有限公司 2026-05-12 CN disclosed
WO-2026068951-A1 5-METHOXY-DMT FOR USE IN THE TREATMENT OF DEPRESSION Beckley Psytech Limited (GB) 2026-04-02 WO disclosed
EP-4712803-A1 MIST INHALATION POD FOR DELIVERING A THERAPEUTIC Shaheen Innovations Holding Limited (AE) 2026-03-25 EP disclosed
US-12521370-B2 Inhalable formulations CYBIN UK LTD (GB) 2026-01-13 US disclosed
EP-4654967-A1 TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS BY PARENTERAL ADMINISTRATION OF A SINGLE, EFFECTIVE PARENTERAL DOSE OF A SHORT-ACTING PSYCHEDELIC AGENT Cybin UK Ltd (GB) 2025-12-03 EP disclosed
US-20250339403-A1 Tryptamine Formulations and Uses Thereof Natural MedTech Pty Ltd (AU) 2025-11-06 US disclosed
WO-2022115798-A2 COMPOSITIONS AND METHODS FOR TREATING MIGRAINE WESANA HEALTH INC. (US) 2022-06-02 WO disclosed
WO-2022079574-A1 COMPOSITIONS FOR REDUCING INFLAMMATION TO IMPROVE OR MAINTAIN MENTAL OR PHYSICAL HEALTH GOODCAP PHARMACEUTICALS LTD. (CA) 2022-04-21 WO disclosed
CN-113979913-A Synthesis of virus-treating medicine N, N-dimethyl-5-hydroxytryptamine-N12Method for producing oxide 河北维达康生物科技有限公司 2022-01-28 CN disclosed
CN-113968810-A Preparation method of N, N-dimethyl-5-hydroxytryptamine 河北维达康生物科技有限公司 2022-01-25 CN disclosed
CN-113956188-A Synthesis method of N, N-dimethyl-5-methoxytryptamine 河北维达康生物科技有限公司 2022-01-21 CN disclosed
CN-113956188-A Synthesis method of N, N-dimethyl-5-methoxytryptamine 河北维达康生物科技有限公司 2022-01-21 CN disclosed
CN-113956188-A Synthesis method of N, N-dimethyl-5-methoxytryptamine 河北维达康生物科技有限公司 2022-01-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220259147-A1 COMPOSITION COMPRISING A BENZOATE SALT OF 5-METHOXY-N,N-DIMETHYLTRYPTAMINE HTR5A, SLC6A4, HTR4 HTR1D 45/4885HTR1A 13/4885HTR1B 26/4885
US-20250339403-A1 Tryptamine Formulations and Uses Thereof MAOA, MAOB, TPH1 HTR1D 45/4885HTR1A 15/4885HTR1B 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.