Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30873954 | 0.83 | FFAR1 (0.58) | FFAR1RXRAP4HTMFFAR4 | |
| SCHEMBL3164361 | 0.81 | CYP11B1 (0.52) | FFAR1CYP11B1CYP11B2P4HTMFFAR4 | |
| SCHEMBL3677264 | 0.80 | FFAR1 (0.66) | FFAR1PPARDRXRAFFAR4MME | |
| SCHEMBL6490922 | 0.79 | FFAR1 (0.58) | FFAR1PPARDRXRALMNATP53 | |
| SCHEMBL7962602 | 0.79 | P4HTM (0.68) | FFAR1LMNAP4HTMTP53FFAR4 | |
| SCHEMBL5300831 | 0.78 | HCAR2 (0.48) | CYP11B1CYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL5293614 | 0.78 | RAB9A (0.54) | CYP11B1CYP11B2KDM4EHPGDTDP1 | |
| SCHEMBL5298125 | 0.78 | FFAR1 (0.61) | FFAR1CYP11B1CYP11B2P4HTMTP53 | |
| SCHEMBL5303734 | 0.78 | MAPK8 (0.44) | CYP11B1CYP11B2LMNAHPGD | |
| SCHEMBL22445719 | 0.77 | LDHA (0.57) | CYP11B1CYP11B2PPARDRXRAP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |