Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306769 | 0.87 | HCAR2 (0.54) | HCAR2CYP2C8CYP2C9LTB4RHPGD | |
| SCHEMBL5293614 | 0.84 | RAB9A (0.54) | HCAR2CYP2C8CYP2C9PKMHTT | |
| SCHEMBL5303734 | 0.83 | MAPK8 (0.44) | HCAR2CYP2C8CYP2C9PKMHTT | |
| SCHEMBL5299672 | 0.80 | HCAR2 (0.53) | HCAR2CYP2C8CYP2C9LTB4RHPGD | |
| SCHEMBL5329176 | 0.79 | DHODH (0.53) | HCAR2CYP2C8CYP2C9LTB4RALDH1A1 | |
| SCHEMBL5301489 | 0.79 | HCAR2 (0.51) | HCAR2PKMHTTKMT2AHPGD | |
| SCHEMBL5307245 | 0.79 | KDM4E (0.52) | HCAR2LTB4RKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL5296276 | 0.78 | FFAR1 (0.55) | HPGDKDM4ECYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL5356977 | 0.78 | ALDH1A1 (0.48) | HCAR2LTB4RKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3554946 | 0.75 | KDM4E (0.47) | HCAR2KMT2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |