SCHEMBL5300637

SCHEMBL5300637

O=C(O)NCCNCc1ccc(Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.59
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
CHRM2 P08172 1/20 0.55
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
RAB9A P51151 4/20 0.50
NPC1 O15118 3/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
MCHR1 Q99705 1/20 0.49
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
POLB P06746 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA9 Q16790 1/20 0.46
CNR1 P21554 1/20 0.46
FOLH1 Q04609 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5303258 0.90 CHRM2 (0.61) ALDH1A1MEN1KMT2ACHRM2CYP2C9
SCHEMBL11296874 0.84 CNR1 (0.61) ALDH1A1MEN1KMT2ACHRM2CYP2C9
SCHEMBL320834 0.83 KMT2A (0.68) ALDH1A1MEN1KMT2ACHRM2CYP2C9
SCHEMBL167573 0.83 MEN1 (0.73) ALDH1A1MEN1KMT2ACYP2C9CYP2C19
SCHEMBL11094422 0.82 CHRM2 (0.75) ALDH1A1MEN1KMT2ACHRM2CYP2C9
SCHEMBL17513300 0.82 MARS1 (0.48) ALDH1A1MEN1KMT2ACHRM2CNR1
SCHEMBL23124836 0.82 L3MBTL1 (0.50) MEN1KMT2ACYP2C19CA12CA1
SCHEMBL23607918 0.82 KDM4E (0.59) ALDH1A1KMT2ACHRM2CYP2C19RAB9A
Hydrochloric Acid SCHEMBL9732830 0.81 KMT2A (0.65) ALDH1A1MEN1KMT2ACHRM2CYP2C9
SCHEMBL4325517 0.81 TSHR (0.55) ALDH1A1MEN1KMT2ACYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007017093-A1 SUBSTITUTED 2-BENZYLOXY-BENZOIC ACID AMIDE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 WO disclosed
WO-2007017092-A1 SUBSTITUTED 4-BENZYLOXY-BENZOIC ACID AMIDE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 WO disclosed