Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287647 | 0.93 | KMT2A (0.49) | KMT2AMEN1HSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL5302367 | 0.91 | ALDH1A1 (0.47) | KMT2AMEN1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL5282895 | 0.83 | ALDH1A1 (0.47) | KMT2AMEN1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL5295624 | 0.83 | ALDH1A1 (0.49) | KMT2AMEN1HSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL5285215 | 0.83 | GSK3A (0.41) | KMT2AMEN1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2294482 | 0.83 | NAMPT (0.48) | KMT2AMEN1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL5295936 | 0.82 | MAPT (0.41) | KMT2AMEN1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2292264 | 0.82 | NPC1 (0.44) | KMT2AMEN1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2295362 | 0.82 | SMN1; SMN2 (0.43) | KMT2AMEN1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL5289381 | 0.81 | ITGB1 (0.44) | SMN1; SMN2NPC1RAB9ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |