Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SELL | P14151 | 3/20 | 0.43 |
| ▸ | SELP | P16109 | 3/20 | 0.43 |
| ▸ | SELE | P16581 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306769 | 0.82 | HCAR2 (0.54) | HCAR2HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL14340837 | 0.80 | HCAR2 (0.63) | HCAR2ALDH1A1L3MBTL1SELLSELP | |
| SCHEMBL5300831 | 0.79 | HCAR2 (0.48) | HCAR2ALDH1A1GAAHSD17B10L3MBTL1 | |
| SCHEMBL5299672 | 0.74 | HCAR2 (0.53) | HCAR2HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL5307245 | 0.73 | KDM4E (0.52) | HCAR2ALDH1A1GAAHSD17B10L3MBTL1 | |
| SCHEMBL3551053 | 0.73 | HCAR2 (0.56) | HCAR2ALDH1A1GAAHSD17B10L3MBTL1 | |
| SCHEMBL5356977 | 0.73 | ALDH1A1 (0.48) | HCAR2ALDH1A1GAAHSD17B10L3MBTL1 | |
| SCHEMBL5329176 | 0.72 | DHODH (0.53) | HCAR2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL3554946 | 0.72 | KDM4E (0.47) | HCAR2ALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL14340845 | 0.70 | HCAR2 (0.67) | HCAR2ALDH1A1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |