Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 14/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306769 | 0.88 | HCAR2 (0.54) | HCAR2LTB4RSMN1; SMN2HPGDKDM4E | |
| SCHEMBL5301209 | 0.84 | HCAR2 (0.59) | HCAR2LTB4R | |
| SCHEMBL5306172 | 0.83 | HCAR2 (0.76) | HCAR2LTB4R | |
| SCHEMBL5062205 | 0.83 | HCAR2 (0.64) | HCAR2LTB4RCYP2C8CYP2C9 | |
| SCHEMBL5300923 | 0.82 | HCAR2 (0.65) | HCAR2LTB4RSMN1; SMN2KDM4E | |
| SCHEMBL5306921 | 0.81 | LTB4R (0.53) | HCAR2LTB4RSMN1; SMN2HPGD | |
| SCHEMBL5329176 | 0.81 | DHODH (0.53) | HCAR2LTB4RCYP2C8CYP2C9 | |
| SCHEMBL5307245 | 0.80 | KDM4E (0.52) | HCAR2LTB4RSMN1; SMN2HPGDKDM4E | |
| SCHEMBL5300831 | 0.80 | HCAR2 (0.48) | HCAR2LTB4RSMN1; SMN2HPGDKDM4E | |
| SCHEMBL5295939 | 0.79 | HCAR2 (0.51) | HCAR2KDM4ECYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |