Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280577 | 0.93 | MAPT (0.38) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL5295212 | 0.83 | POLB (0.43) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL5284187 | 0.82 | GHSR (0.47) | RAB9ANPC1SMN1; SMN2LMNANR1I2 | |
| SCHEMBL5306255 | 0.79 | ALDH1A1 (0.37) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2296252 | 0.78 | NR1I2 (0.47) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2296670 | 0.78 | NR1I2 (0.47) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2295674 | 0.77 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2296379 | 0.77 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2300786 | 0.77 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL5284712 | 0.77 | POLB (0.43) | SMN1; SMN2KMT2AKDM4EMEN1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |