Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212302 | 0.85 | SMN1; SMN2 (0.50) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5215761 | 0.84 | ALOX15 (0.52) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5216679 | 0.83 | SMN1; SMN2 (0.49) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5215957 | 0.83 | SMN1; SMN2 (0.60) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5214681 | 0.83 | HTR4 (0.46) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5306266 | 0.81 | HTR4 (0.47) | HTR4GNAI3GNAO1GNAI1 | |
| SCHEMBL5217099 | 0.81 | HTR4 (0.48) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5219357 | 0.80 | HTR4 (0.50) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL5216773 | 0.80 | SMN1; SMN2 (0.42) | HTR4ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL27748790 | 0.77 | ALDH1A1 (0.51) | ALDH1A1GAASMN1; SMN2LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |