Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335241 | 0.94 | KCNH3 (0.41) | KCNH3PRSS1MAPTALDH1A1F2 | |
| SCHEMBL5308535 | 0.86 | MAPT (0.43) | KCNH3MAPTALDH1A1MEN1NPC1 | |
| SCHEMBL1567049 | 0.78 | KCNH3 (0.65) | KCNH3PRSS1MAPTALDH1A1F2 | |
| SCHEMBL27421361 | 0.78 | TRPV1 (0.38) | PRSS1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11560139 | 0.76 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11070951 | 0.76 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL23630857 | 0.76 | KCNH3 (0.63) | KCNH3PRSS1MAPTALDH1A1F2 | |
| SCHEMBL15822970 | 0.76 | KCNH3 (0.63) | KCNH3PRSS1MAPTALDH1A1F2 | |
| SCHEMBL12932913 | 0.75 | ALDH1A1 (0.40) | MAPTALDH1A1MEN1NPC1XBP1 | |
| SCHEMBL8244931 | 0.75 | KCNH3 (0.57) | KCNH3MAPTALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |