Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | CCR2 | P41597 | 6/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.52 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.52 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589388 | 0.85 | CCR2 (0.54) | METAP2CCR2 | |
| SCHEMBL7595505 | 0.81 | KEAP1 (0.59) | CCR2FFAR4 | |
| SCHEMBL5956125 | 0.81 | ALDH1A1 (0.59) | METAP2ALDH1A1FFAR4 | |
| SCHEMBL5309797 | 0.79 | EP300 (0.68) | — | |
| SCHEMBL7590886 | 0.79 | MEN1 (0.61) | — | |
| SCHEMBL5899919 | 0.78 | MCL1 (0.69) | CES1CCR2CYP19A1ALDH1A1APP | |
| SCHEMBL15830620 | 0.77 | APP (0.61) | CES1METAP2CCR2CYP19A1ALDH1A1 | |
| SCHEMBL7590717 | 0.77 | KEAP1 (0.62) | CYP19A1ALDH1A1FFAR4 | |
| SCHEMBL7594450 | 0.77 | CA2 (0.58) | CYP19A1ALDH1A1 | |
| SCHEMBL7594857 | 0.77 | CA1 (0.54) | METAP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |