SCHEMBL5310100

SCHEMBL5310100

COc1ccc2c(-c3ccc(Cl)cc3)coc(=O)c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.50
PIN1 Q13526 1/20 0.50
MAPT P10636 6/20 0.49
KDM4E B2RXH2 5/20 0.49
ALDH1A1 P00352 5/20 0.49
NPC1 O15118 4/20 0.49
RAB9A P51151 4/20 0.49
SMN1; SMN2 Q16637 4/20 0.49
MEN1 O00255 3/20 0.49
TP53 P04637 3/20 0.49
CYP3A4 P08684 3/20 0.49
KMT2A Q03164 3/20 0.49
HPGD P15428 3/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
MAOB P27338 6/20 0.48
CYP19A1 P11511 1/20 0.47
MAOA P21397 4/20 0.47
HSD17B10 Q99714 3/20 0.47
BCL2 P10415 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4745653 0.82 PIN1 (0.73) XDHPIN1MAPTKDM4EALDH1A1
SCHEMBL12289033 0.81 XDH (0.76) XDHPIN1MAPTKDM4EALDH1A1
SCHEMBL5311985 0.74 ROCK1 (0.53) MAPTKDM4EALDH1A1SMN1; SMN2MEN1
SCHEMBL31604200 0.74 MAPT (0.49) XDHMAPTKDM4EALDH1A1NPC1
SCHEMBL571576 0.71 XDH (0.84) XDHPIN1MAPTKDM4EALDH1A1
SCHEMBL5308206 0.71 MEN1 (0.52) MAPTKDM4ENPC1RAB9AMEN1
SCHEMBL29640433 0.71 RAB9A (0.67) XDHMAPTKDM4EALDH1A1NPC1
SCHEMBL31604205 0.71 HTT (0.49) XDHMAPTKDM4EALDH1A1NPC1
SCHEMBL30629181 0.71 KDM4E (0.79) MAPTKDM4EALDH1A1NPC1RAB9A
SCHEMBL28172130 0.71 RAB9A (0.67) XDHMAPTKDM4EALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007042668-A1 DERIVATIVES OF 1-AMINO-ISOQUINOLINE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS IN THE TREATMENT OF A DYSFUNCTION ASSOCIATED WITH MCH RECEPTOR 1 SANOFI-AVENTIS (FR) 2007-04-19 WO disclosed
WO-2007042668-A1 DERIVATIVES OF 1-AMINO-ISOQUINOLINE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS IN THE TREATMENT OF A DYSFUNCTION ASSOCIATED WITH MCH RECEPTOR 1 SANOFI-AVENTIS (FR) 2007-04-19 WO disclosed