Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 6/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329482 | 0.88 | KDM4E (0.48) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5309106 | 0.87 | HPGD (0.41) | DHODH | |
| SCHEMBL5313055 | 0.86 | KDM4E (0.52) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5307867 | 0.85 | ABL1 (0.41) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5329820 | 0.82 | ADORA2A (0.41) | KDM4EKMT2ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL5313191 | 0.82 | KDM4E (0.50) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL1585290 | 0.74 | KDM4E (0.83) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5311966 | 0.73 | SCD (0.45) | KDM4EDHODH | |
| SCHEMBL5315830 | 0.73 | ASPH (0.48) | ASPH | |
| SCHEMBL5307458 | 0.73 | DPP4 (0.41) | L3MBTL1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044085-A2 | HETEROARYL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-04-19 | — | — | WO | disclosed |