Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.39 |
| ▸ | DHODH | Q02127 | 4/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313055 | 0.87 | KDM4E (0.52) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5310745 | 0.82 | KDM4E (0.49) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5329482 | 0.81 | KDM4E (0.48) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL1585290 | 0.75 | KDM4E (0.83) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5334708 | 0.75 | RBP4 (0.42) | ASPHKDM4CDHODHELANEMAPT | |
| SCHEMBL5307458 | 0.74 | DPP4 (0.41) | L3MBTL1DHODH | |
| SCHEMBL5313178 | 0.73 | LMNA (0.44) | KDM4EHTTELANEMAPTGSK3A | |
| SCHEMBL5307816 | 0.72 | HCRTR1 (0.43) | — | |
| SCHEMBL5313034 | 0.72 | MGLL (0.45) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5311601 | 0.72 | PTGES (0.44) | KDM4EGLAHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044085-A2 | HETEROARYL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-04-19 | — | — | WO | disclosed |