Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 5/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | LTC4S | Q16873 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310745 | 0.88 | KDM4E (0.49) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5313055 | 0.85 | KDM4E (0.52) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5313191 | 0.81 | KDM4E (0.50) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5309106 | 0.78 | HPGD (0.41) | DHODHSCD | |
| SCHEMBL5307867 | 0.77 | ABL1 (0.41) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5307458 | 0.74 | DPP4 (0.41) | L3MBTL1DHODHMGLLSCD | |
| SCHEMBL5329820 | 0.74 | ADORA2A (0.41) | KDM4EKMT2ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1585290 | 0.74 | KDM4E (0.83) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5307816 | 0.73 | HCRTR1 (0.43) | SCD | |
| SCHEMBL5311601 | 0.73 | PTGES (0.44) | KDM4EGLAHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044085-A2 | HETEROARYL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-04-19 | — | — | WO | disclosed |