Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749417 | 0.84 | NPC1 (0.47) | APPRAB9AKDM4ENPC1ALDH1A1 | |
| SCHEMBL23172529 | 0.83 | RAB9A (0.40) | APPRAB9AKDM4ENPC1ALDH1A1 | |
| SCHEMBL15747062 | 0.83 | ALOX5 (0.43) | APPRAB9AKDM4ENPC1MGLL | |
| SCHEMBL23458481 | 0.83 | KDM4E (0.59) | RAB9AKDM4ENPC1CYP19A1ALDH1A1 | |
| SCHEMBL29064014 | 0.82 | KDM4E (0.46) | RAB9AKDM4ENPC1CYP19A1ALDH1A1 | |
| SCHEMBL15746019 | 0.80 | TNF (0.61) | APPRAB9AKDM4ENPC1ALDH1A1 | |
| SCHEMBL13189380 | 0.80 | APP (0.61) | APPMAPTGLAGAAMEN1 | |
| SCHEMBL26833290 | 0.78 | DCTPP1 (0.43) | APPRAB9AKDM4ENPC1CYP19A1 | |
| SCHEMBL12910392 | 0.77 | RAB9A (0.43) | APPRAB9AKDM4ENPC1ALDH1A1 | |
| SCHEMBL21496679 | 0.76 | HRH3 (0.41) | RAB9AKDM4ENPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |