Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9969418 | 0.77 | GSR (0.56) | GSREPHX2NR1H4MMP2MMP9 | |
| SCHEMBL8388265 | 0.77 | EPHX2 (0.46) | GSREPHX2GAAPTGS2KMT2A | |
| SCHEMBL6656686 | 0.73 | GSR (0.51) | GSREPHX2NR1H4MMP2MMP9 | |
| SCHEMBL10541229 | 0.72 | GSR (0.54) | GSREPHX2NR1H4MMP2MMP9 | |
| SCHEMBL9700367 | 0.72 | GSR (0.57) | GSREPHX2NR1H4MMP2MMP9 | |
| SCHEMBL10745014 | 0.71 | GSR (0.56) | GSRMMP2MMP9MMP8AKR1C3 | |
| SCHEMBL29110133 | 0.69 | SRC (0.56) | GAAKMT2A | |
| SCHEMBL25876517 | 0.69 | GSR (0.57) | GSREPHX2NR1H4MMP2MMP9 | |
| SCHEMBL2657688 | 0.68 | EPHX2 (0.46) | EPHX2NR1H4KMT2A | |
| SCHEMBL28296252 | 0.68 | GSR (0.53) | GSREPHX2NR1H4MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |